Tretinoin cream USP 0.025% is a medication used topically to treat acne vulgaris and to reduce the appearance of fine wrinkles, sun damage, and uneven skin tone. It is a type of retinoid that works by increasing cell turnover and promoting the shedding of dead skin cells, which can help to unclog pores and prevent new acne lesions from forming. Retino A Cream should be applied once daily, typically at night, to clean, dry skin. It is important to use only a pea-sized amount and to avoid applying it to sensitive areas such as the lips and eyes.